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What is the mechanism of action for digoxin? It is extracted from the leaves of a plant called digitalis lanata. Digoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzyme (ATPase) that controls movement of calcium, sodium, and potassium into heart muscle. Calcium controls the force of contraction.
What is the most expensive medication? The US Food and Drug Administration on Friday approved what will be the most expensive drug in the world, a gene therapy from Novartis that treats spinal muscular atrophy at a cost of $2.1m.
Who invented digitalis? Digitalis was first prescribed by English physician and botanist William Withering (1741–99), who used it in the treatment of edema (dropsy).
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