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Since blocking CTLA4 could bolster the immune response spurred by the vaccine, researchers studied whether combining GVAX vaccines with monoclonal antibody therapy could lengthen remissions and quell the inflammatory problems associated with antibody therapy alone.

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It is important to note that in human subjects these are merely observational and coincident changes in multiple signaling pathways; causal relationships between impairments in oxidative metabolism and mitochondrial function with insulin resistance is not established (), and indeed there is evidence that in the condition of primary congenital insulin resistance, mitochondrial dysfunction follows ().

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Ablation of GLUT4 specifically in skeletal muscle led to glucose intolerance and severe impairments in insulin-mediated glucose disposal into muscle in mice as young as 8 weeks of age ().

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Though aon the UKPDS showed that just being in the intervention group reduced heart attacks and strokes 10 years after the follow up period, imagine how many heart attacks and strokes might have been prevented had patients maintained glycemic control over a much longer period of time!

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Retroviral delivery of short hairpin RNA into 3T3L1 adipocytes yielding reduced Lcn2 expression was associated with improved insulin action while exogenous Lcn2 promoted insulin resistance in cultured hepatocytes ().

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